{"id":7098,"date":"2023-09-07T23:23:45","date_gmt":"2023-09-07T22:23:45","guid":{"rendered":"https:\/\/molbio-api.massgeneral.org\/?post_type=labs&#038;p=7098"},"modified":"2023-09-07T23:29:18","modified_gmt":"2023-09-07T22:29:18","slug":"strecker-lab","status":"publish","type":"labs","link":"https:\/\/molbio-api.massgeneral.org\/labs\/strecker-lab\/","title":{"rendered":"Strecker Lab"},"template":"","meta":[],"class_list":["post-7098","labs","type-labs","status-publish","hentry"],"acf":{"title_override":"Strecker Lab","header_text":"","header_image":false,"has_contents":false,"header_button_text":"","new_tab":false,"header_button_link":"","header_button_is_top":false,"header_button_icon":"","background_color":"white","background_anchor_point":"","featured_image":{"ID":7090,"id":7090,"title":"Strecker_headshot","filename":"Strecker_headshot.png","filesize":3144212,"url":"https:\/\/molbio-api.massgeneral.org\/wp-content\/uploads\/2023\/09\/Strecker_headshot.png","link":"https:\/\/molbio-api.massgeneral.org\/people\/jonathan-strecker\/strecker_headshot\/","alt":"","author":"3","description":"","caption":"","name":"strecker_headshot","status":"inherit","uploaded_to":7096,"date":"2023-09-07 22:03:27","modified":"2024-04-04 17:59:52","menu_order":0,"mime_type":"image\/png","type":"image","subtype":"png","icon":"https:\/\/molbio-api.massgeneral.org\/wp-includes\/images\/media\/default.png","width":1562,"height":1952,"sizes":{"thumbnail":"https:\/\/molbio-api.massgeneral.org\/wp-content\/uploads\/2023\/09\/Strecker_headshot-150x150.png","thumbnail-width":150,"thumbnail-height":150,"medium":"https:\/\/molbio-api.massgeneral.org\/wp-content\/uploads\/2023\/09\/Strecker_headshot-240x300.png","medium-width":240,"medium-height":300,"medium_large":"https:\/\/molbio-api.massgeneral.org\/wp-content\/uploads\/2023\/09\/Strecker_headshot-768x960.png","medium_large-width":768,"medium_large-height":960,"large":"https:\/\/molbio-api.massgeneral.org\/wp-content\/uploads\/2023\/09\/Strecker_headshot-819x1024.png","large-width":819,"large-height":1024,"1536x1536":"https:\/\/molbio-api.massgeneral.org\/wp-content\/uploads\/2023\/09\/Strecker_headshot-1229x1536.png","1536x1536-width":1229,"1536x1536-height":1536,"2048x2048":"https:\/\/molbio-api.massgeneral.org\/wp-content\/uploads\/2023\/09\/Strecker_headshot.png","2048x2048-width":1562,"2048x2048-height":1952}},"featured_content":"<p><strong>Jonathan Strecker, PhD<br \/>\n<\/strong>Principal Investigator<br \/>\nHarvard Medical School<\/p>\n<hr \/>\n<p><strong>Contact<br \/>\n<\/strong><a href=\"mailto:strecker@molbio.mgh.harvard.edu\">strecker@molbio.mgh.harvard.edu<\/a><strong><br \/>\n<\/strong><\/p>\n<p>MGH Department of Molecular Biology<br \/>\nSimches Research Center<br \/>\n185 Cambridge Street<br \/>\nBoston, MA 02114<\/p>\n<hr \/>\n<p><strong>Website<br \/>\n<\/strong><a href=\"https:\/\/thestreckerlab.org\">Strecker Lab<\/a><\/p>\n<hr \/>\n<p><strong>Publications<br \/>\n<\/strong><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Jonathan+Strecker\">PubMed<\/a><\/p>\n","flexible_content":[{"acf_fc_layout":"title_block","size":"medium","text":"Prokaryotic immunity, CRISPR-Cas systems, and programmable biological functions"},{"acf_fc_layout":"text_block","text_block":"<p style=\"text-align: justify; line-height: normal; margin: 0px;\">Our lab is broadly interested in the biology of immune proteins found throughout nature. Bacteria have evolved numerous defenses against phage, including CRISPR-Cas systems, and while these predominantly function as RNA-guided nucleases, additional functions exist including CRISPR-associated transposases that perform RNA-targeted DNA insertion, and CRISPR-associated proteases that cleave protein substrates upon RNA detection.<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: justify; margin: 0px;\">We are interested in how cells sense and respond to nucleic acids and how diverse enzymes can be controlled in a programmable manner. Our long-term goal is to use these basic discoveries to enable new functions in biology and to contribute to our understanding of the human genome.<\/p>\n"}]},"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.7.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Strecker Lab - Molbio<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/molbio-api.massgeneral.org\/labs\/strecker-lab\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Strecker Lab - Molbio\" \/>\n<meta property=\"og:url\" content=\"https:\/\/molbio-api.massgeneral.org\/labs\/strecker-lab\/\" \/>\n<meta property=\"og:site_name\" content=\"Molbio\" \/>\n<meta property=\"article:modified_time\" content=\"2023-09-07T22:29:18+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/molbio-api.massgeneral.org\/labs\/strecker-lab\/\",\"url\":\"https:\/\/molbio-api.massgeneral.org\/labs\/strecker-lab\/\",\"name\":\"Strecker Lab - Molbio\",\"isPartOf\":{\"@id\":\"https:\/\/molbio-api.massgeneral.org\/#website\"},\"datePublished\":\"2023-09-07T22:23:45+00:00\",\"dateModified\":\"2023-09-07T22:29:18+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/molbio-api.massgeneral.org\/labs\/strecker-lab\/#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/molbio-api.massgeneral.org\/labs\/strecker-lab\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/molbio-api.massgeneral.org\/labs\/strecker-lab\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/molbio-api.massgeneral.org\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Labs\",\"item\":\"https:\/\/molbio-api.massgeneral.org\/labs\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Strecker Lab\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/molbio-api.massgeneral.org\/#website\",\"url\":\"https:\/\/molbio-api.massgeneral.org\/\",\"name\":\"Molbio\",\"description\":\"The Department of Molecular Biology at MGH. 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